Protein-metal interactions

Discovering Domains Mediating Protein Interactions

Background: Protein-protein interactions do not provide any direct information re‌garding the domains within the proteins that mediate the interactions. The majority of proteins are multi domain proteins and the interaction between them is often defined by the pairs of their domains. Most of the former studies focus only on interacting do‌main pairs. However they do not consider the in...

Final Report : High Stability Metal - Protein Interactions Evaluated

Number of Papers published in peer-reviewed journals: Number of Papers published in non peer-reviewed journals: Final Report: High Stability Metal-Protein Interactions Evaluated by Microcalorimetry Report Title Isothermal titration calorimetry (ITC) is a microcalorimetry technique used to study interactions between biomolecules and ligands in aqueous solution. This ARO equipment grant was provi...

discovering domains mediating protein interactions

background: protein-protein interactions do not provide any direct information re­garding the domains within the proteins that mediate the interactions. the majority of proteins are multi domain proteins and the interaction between them is often defined by the pairs of their domains. most of the former studies focus only on interacting do­main pairs. however they do not consider the interaction...

Metal–DNA interactions

Metal ions can bind to DNA directly or indirectly through hydrogen bonding of the coordinating water molecules surrounding the metal ions. Metal binding to the bases usually disrupts base pair hydrogen bonding and destabilizes the double helix. Spectroscopic and X-ray data shows that the N7 atom of the purine or N3 of pyrimidine residues as well as exocyclic O atoms and the phosphate oxygen ato...

Metal/Nucleic-Acid Interactions